An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response
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چکیده
منابع مشابه
An overlapping protein-coding region in influenza A virus segment 3 modulates the host response.
Influenza A virus (IAV) infection leads to variable and imperfectly understood pathogenicity. We report that segment 3 of the virus contains a second open reading frame ("X-ORF"), accessed via ribosomal frameshifting. The frameshift product, termed PA-X, comprises the endonuclease domain of the viral PA protein with a C-terminal domain encoded by the X-ORF and functions to repress cellular gene...
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ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1222213